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GLP-1s don't always work for weight loss. Researchers are trying to figure out why

By Yuki Noguchi

Published December 22, 2025 at 2:45 AM MST

GLP-1 weight loss drugs have transformed obesity treatment, but not everyone loses lots of weight. Researchers say figuring out why is the key to the future of this treatment method.

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Yuki Noguchi

Yuki Noguchi is a correspondent on the Science Desk based out of NPR's headquarters in Washington, D.C. She started covering consumer health in the midst of the pandemic, reporting on everything from vaccination and racial inequities in access to health, to cancer care, obesity and mental health.